Potassium Fluoride → HCID 22049881、化合物

HRID 1830930ノート

反応式

HRID 1830930 の反応式
[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[F-:14].[K+]>CC(C)=O.O.CCOC(C)=O>[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([S:10]([F:14])(=[O:12])=[O:11])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1

参加物

6

反応物 2

HCID 522689Potassium FluorideHCID 220498824-Cyclopropylbenzenesulphonyl chloride

生成物 1

HCID 22049881HCID 22049881、化合物収率 97%

試薬・触媒・溶媒 3

HCID 180Acetone溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Crude compound 45 (13.3 g) was dissolved in 200 mL of acetone and 60 mL of water. Potassium fluoride (7.12 g, 122 mmol) was added and the reaction mixture was stirred overnight at rt. The reaction mixture was diluted with EtOAc and washed with water. The organic layer was dried with Na2SO4, filtered, and concentrated to dryness to give 9.80 g (97%) of crude p-cyclopropyl benzenesulfonyl fluoride (Compound 46).

後処理

  1. washwashed with water
  2. dry with materialThe organic layer was dried with Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-742ff3e8909c4e08b0bb6e3d82f1effe
出典データセット
uspto-grants-2006_06
特許番号
US07067539B2

反応ノート

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