Pyridinium chloride → 1-(5-Hydroxy-pyrimidin-2-yl)-4,4-dimethyl-piperidine-2,6-dione

HRID 1831055ノート

反応式

HRID 1831055 の反応式
C[O:2][C:3]1[CH:4]=[N:5][C:6]([N:9]2[C:14](=[O:15])[CH2:13][C:12]([CH3:17])([CH3:16])[CH2:11][C:10]2=[O:18])=[N:7][CH:8]=1.Cl.N1C=CC=CC=1>ClCCl>[OH:2][C:3]1[CH:4]=[N:5][C:6]([N:9]2[C:10](=[O:18])[CH2:11][C:12]([CH3:16])([CH3:17])[CH2:13][C:14]2=[O:15])=[N:7][CH:8]=1

参加物

4

反応物 2

HCID 10176127Pyridinium chlorideHCID 220478711-(5-Methoxy-pyrimidin-2-yl)-4,4-dimethyl-piperidine-2,6-dione

生成物 1

HCID 220477581-(5-Hydroxy-pyrimidin-2-yl)-4,4-dimethyl-piperidine-2,6-dione収率 64.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
190 °C

実験手順

A mixture of 1-(5-methoxy-pyrimidin-2-yl)-4,4-dimethyl-piperidine-2,6-dione (0.99 g, 3.97 mmol) and pyridine hydrochloride (1.50 g, 7.99 mmol) was heated at 190° C. for 2.5 hours. After cooling to room temperature the reaction mixture was dissolved in a small amount of dichloromethane and filtered over a short pad of silicagel and washed with ethyl acetate. Evaporation of the solvent in vacuo yielded the title compound (0.60 g, 64% yield) as a white solid.

後処理

  1. temperatureAfter cooling to room temperature the reaction mixture
  2. filtrationfiltered over a short pad of silicagel
  3. washwashed with ethyl acetate
  4. customEvaporation of the solvent in vacuo

出典と根拠

ORDレコード
ord-b6428968b7f7486d8edc40883ebeea4d
出典データセット
uspto-grants-2006_06
特許番号
US07067517B2

反応ノート

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