tert-Butyldimethylsilyl chloride → HCID 22047954、化合物

HRID 1831060ノート

反応式

HRID 1831060 の反応式
[Si:1](Cl)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[OH:9][CH:10]1[CH2:15][CH2:14][N:13]([C:16]([N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[O:17])[CH2:12][CH2:11]1>CN(C)C=O>[C:4]([Si:1]([CH3:3])([CH3:2])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([C:16]([N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[O:17])[CH2:12][CH2:11]1)([CH3:7])([CH3:6])[CH3:5]

参加物

4

反応物 2

HCID 28928tert-Butyldimethylsilyl chlorideHCID 22047711(4-Hydroxy-piperidin-1-yl)-imidazol-1-yl-methanone

生成物 1

HCID 22047954HCID 22047954、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

tert-Butyldimethylsilyl chloride (30.14 g, 0.20 mol) was added to a stirred solution of (4-hydroxy-piperidin-1-yl)-imidazol-1-yl-methanone (39.05 g, 0.20 mol) in dimethylformamide (200 mL). After stirring for 3 days at room temperature, the solvent was removed by evaporation in vacuo. The residue was redissolved in dichloromethane, extracted twice with water, dried over sodium sulphate, filtered and evaporated in vacuo, yielding the title compound, which was used without further purification.

後処理

  1. customthe solvent was removed by evaporation in vacuo
  2. dissolutionThe residue was redissolved in dichloromethane
  3. extractionextracted twice with water
  4. dry with materialdried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-0d3263e0e4f84ef49d20f6da1017f5e2
出典データセット
uspto-grants-2006_06
特許番号
US07067517B2

反応ノート

読み込み中…