Pyridinium chloride → 2(1H)-Pyridinone, 5-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-

HRID 1831072

反応式

HRID 1831072 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=2)=[CH:5][N:4]=1.Cl.N1C=CC=CC=1>ClCCl>[F:19][C:16]([F:17])([F:18])[C:13]1[CH:14]=[CH:15][C:10]([O:9][C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[N:4][CH:5]=2)=[N:11][CH:12]=1

参加物

4

反応物 2

HCID 10176127Pyridinium chlorideHCID 22047745Pyridine, 2-[(6-methoxy-3-pyridinyl)oxy]-5-(trifluoromethyl)-

生成物 1

HCID 1785162742(1H)-Pyridinone, 5-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-収率 68%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
200 °C

実験手順

A mixture of 2-methoxy-5-(5-trifluoromethyl-pyridin-2-yloxy)-pyridine (0.28 g, 1.04 mmol) and pyridine hydrochloride (1.00 g, 8.65 mmol) was heated in a kugelrohr oven at 200° C. for 10 minutes. After cooling to room temperature, the reaction mixture is dissolved in dichloromethane and extracted with water, dried over sodium sulphate, filtered and evaporated in vacuo, yielding the title compound (180 mg, 68% yield) as a white solid.

後処理

  1. temperatureAfter cooling to room temperature
  2. extractionextracted with water
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-fc869a2efc724db9817acdd4c72124b4
出典データセット
uspto-grants-2006_06
特許番号
US07067517B2

関連ノート

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