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Potassium Bromide → 4-(2-Chloro-6-fluoro-benzyl)-piperazine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Bromide | HCID 253877 | — |
| 反応物 | 1-((2-Chloro-6-fluorophenyl)methyl)piperazine | HCID 735737 | — |
| 反応物 | 4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047762 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(2-Chloro-6-fluoro-benzyl)-piperazine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester | HCID 57455831 | — |
反応手順
The hydrochloride of the title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-(2-chloro-6-fluorobenzyl)piperazine. White crystals, m.p. 204–205° C. (from ethanol); HPLC-MS m/z=510 (M+H); IR (KBr): ν 1726 (C═O) cm−1;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07067517B2 |
| 出典データセット | uspto-grants-2006_06 |
| ORD ID | ord-7168c1c05d8e4081ba020e1c3875c208 |
| 出典メモ | uspto-grants-2006_06 |