関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Styrene | HCID 7501 | — |
| 反応物 | N-Methyl dicyclohexylamine | HCID 24210 | — |
| 反応物 | Methyl-phenyl-carbamic Acid 4-iodo-phenyl Ester | HCID 69517304 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 触媒 | HCID 178418851 | HCID 178418851 | — |
| 生成物 | Methyl-phenyl-carbamic acid 4-styryl-phenyl ester | HCID 69517626 | 17% |
反応手順
Styrene (1.2 mmol), N-methyldicyclohexylamine (1.2 mmol), Pd2(dba)3 (0.03 mmol), Pd(P(t-Bu)3)2 (0.06 mmol) and methyl-phenyl-carbamic acid 4-iodo-phenyl ester (1.0 mmol) were added to a Schlenk tube under nitrogen. The Schlenk tube was evacuated and refilled with nitrogen five times. Then dioxane (2 mL) was added and the reaction mixture was stirred at 70° C. for 8 h. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) giving the title compound in 17% yield as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07067517B2 |
|---|
| 出典データセット | uspto-grants-2006_06 |
|---|
| ORD ID | ord-49393bbb9461493097fe5b44df1672b2 |
|---|
| 出典メモ | uspto-grants-2006_06 |
|---|
