Sodium Dithionite → 4-(2,4-dichloro-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine

HRID 1831514

反応式

HRID 1831514 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:15][CH:16]([CH2:19][O:20][CH3:21])[CH2:17][CH3:18])[C:10]=1[N+:22]([O-])=O.[O-]S(S([O-])=O)=O.[Na+].[Na+]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:15][CH:16]([CH2:19][O:20][CH3:21])[CH2:17][CH3:18])[C:10]=1[NH2:22]

参加物

3

反応物 2

HCID 24489Sodium DithioniteHCID 22052219[4-(2,4-Dichloro-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine

生成物 1

HCID 696580374-(2,4-dichloro-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine収率 57%

実験手順

[4-(2,4-Dichloro-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine (0.25 g, 0.67 mmol) and Na2S2O4 (0.95 g, 5.45 mmol) were treated substantially as described in Part E of Example 9 to yield 0.13 g (56%) of 4-(2,4-dichloro-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine: MS (AP) m/z 340.3 [(M+H)+, 100].

出典と根拠

ORDレコード
ord-43e412cc3d72443a961852d8f2ca6a0d
出典データセット
uspto-grants-2006_06
特許番号
US07067658B2

関連ノート

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