Sodium Dithionite → 4-(2-chloro-4-methoxy-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine

反応式

[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][N:13]=[C:12]([NH:16][CH:17]([CH3:21])[CH2:18][O:19][CH3:20])[C:11]=1[N+:22]([O-])=O.[O-]S(S([O-])=O)=O.[Na+].[Na+]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][N:13]=[C:12]([NH:16][CH:17]([CH3:21])[CH2:18][O:19][CH3:20])[C:11]=1[NH2:22]

参加物

反応物 2

HCID 24489Sodium Dithionite

HCID 22052173[4-(2-Chloro-4-methoxy-phenyl)-3-nitro-pyridin-2-yl]-(2-methoxy-1-methyl-ethyl)-amine

生成物 1

HCID 696581484-(2-chloro-4-methoxy-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine収率 85.5%

実験手順

[4-(2-chloro-4-methoxy-phenyl)-3-nitro-pyridin-2-yl]-(2-methoxy-1-methyl-ethyl)-amine (0.28 g, 0.80 mmol) and Na2S2O4 (1.12 g, 6.42 mmol) were treated substantially as described in Part E of Example 9 to give 0.22 g (84%) 4-(2-chloro-4-methoxy-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine: MS (AP) m/z 321.8 [(M+H)+, 72].

出典と根拠

ORDレコード: ord-b542bc15f7914dae86056b0ac6fba0fc
出典データセット: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07067658B2

反応ノート

読み込み中…