4-benzyloxy-1-(3-fluorobenzyl)-1H-pyridin-2-one → HCID 54724162、化合物

HRID 1831903ノート

反応式

HRID 1831903 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)[C:11](=[O:23])[CH:10]=1)C1C=CC=CC=1>C(O)C>[F:22][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[CH2:15][N:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]1=[O:23]

参加物

3

反応物 1

HCID 220502224-benzyloxy-1-(3-fluorobenzyl)-1H-pyridin-2-one

生成物 1

HCID 54724162HCID 54724162、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In a Fischer-Porter bottle, added a solution of 4-(benzyloxy)-1-(3-fluorobenzyl)pyridin-2(1H)-one (4.5 g, 14.56 mmol) in absolute ethanol-(20 mL). Flushed the solution with nitrogen then added palladium catalyst (1.05 g). Sealed bottle and evacuated system. The system was purged with hydrogen gas (2×15 psi) to check for leaks. The reaction was charged with hydrogen (35 psi) and stirred at room temperature for 45 min. The system was evacuated and flushed with nitrogen. The reaction was filtered and the catalyst was carefully washed with fresh ethanol. The filtrate was concentrated under reduced pressure.

後処理

  1. customFlushed the solution with nitrogen
  2. customSealed bottle
  3. customevacuated system
  4. customThe system was purged with hydrogen gas (2×15 psi)
  5. additionThe reaction was charged with hydrogen (35 psi)
  6. customThe system was evacuated
  7. customflushed with nitrogen
  8. filtrationThe reaction was filtered
  9. washthe catalyst was carefully washed with fresh ethanol
  10. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-c4bb582f305842b0b53556a4f1ff4944
出典データセット
uspto-grants-2006_06
特許番号
US07067540B2

反応ノート

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