4-Amino-2-methyl-5-pyrimidinemethanamine → HCID 54724214、化合物

HRID 1831992

反応式

HRID 1831992 の反応式
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])O[C:4](=[O:9])[CH:3]=1.[NH2:10][C:11]1[C:16]([CH2:17][NH2:18])=[CH:15][N:14]=[C:13]([CH3:19])[N:12]=1>O>[NH2:10][C:11]1[C:16]([CH2:17][N:18]2[C:6]([CH3:8])=[CH:7][C:2]([OH:1])=[CH:3][C:4]2=[O:9])=[CH:15][N:14]=[C:13]([CH3:19])[N:12]=1

参加物

4

反応物 2

HCID 667624-Amino-2-methyl-5-pyrimidinemethanamineHCID 546757574-Hydroxy-6-methyl-2-pyrone

生成物 1

HCID 54724214HCID 54724214、化合物収率 58.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4-hydroxy-6-methyl-2-pyrone (0.9 g, 0.007 mol) and 4-amino-5-aminomethyl-2-methylpyrimidine (1.0 g, 0.007 mol) in water (10.0 ml) was heated at 100° C. for 1 h under argon atmosphere. The reaction mixture was cooled, and filtered the yellow precipitate. It was washed successively with cold water, ethanol, and dried in vacuo to afford the title compound (1.01 g, 51%) as a pale yellow powder: 1H NMR (DMSO-d6/400 MHz) δ 7.62 (s, 1H), 7.04 (s, 1H), 5.83 (d, 1H, J=2.0 Hz), 5.58 (d, 1H, J=2.0 Hz), 4.92 (s, 2H), 2.24 (s, 3H), and 2.22 (s, 3H); ES-HRMS m/z 325.0304 (M+H C12H14N4O2Br requires 325.0295). Step 2 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-bromo-4-hydroxy-6-methylpyridin-2(1H)-one

後処理

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered the yellow precipitate
  3. washIt was washed successively with cold water, ethanol
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-3dba739c2a4d4cffbeddd87551f97052
出典データセット
uspto-grants-2006_06
特許番号
US07067540B2

関連ノート

読み込み中…