1-(4-Nitrophenyl)-5-(trifluoromethyl)pyrazole-4-carbonyl chloride → N-((1S)-3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl)-1-phenylpropyl)-1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

HRID 1832486

反応式

HRID 1832486 の反応式
[NH2:1][C@H:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[N+:29]([C:32]1[CH:37]=[CH:36][C:35]([N:38]2[C:42]([C:43]([F:46])([F:45])[F:44])=[C:41]([C:47](Cl)=[O:48])[CH:40]=[N:39]2)=[CH:34][CH:33]=1)([O-:31])=[O:30]>>[C:18]([NH:17][C:13]1[CH:12]=[C:11]([CH:8]2[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][C@H:2]([NH:1][C:47]([C:41]3[CH:40]=[N:39][N:38]([C:35]4[CH:36]=[CH:37][C:32]([N+:29]([O-:31])=[O:30])=[CH:33][CH:34]=4)[C:42]=3[C:43]([F:44])([F:45])[F:46])=[O:48])[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:6][CH2:7]2)[CH:16]=[CH:15][CH:14]=1)(=[O:22])[CH:19]([CH3:21])[CH3:20]

参加物

3

反応物 2

HCID 27757461-(4-Nitrophenyl)-5-(trifluoromethyl)pyrazole-4-carbonyl chlorideHCID 69523474N-(3-(1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl)phenyl)-2-methylpropanamide

生成物 1

HCID 58651320N-((1S)-3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl)-1-phenylpropyl)-1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

実験手順

Prepared by Procedure Q1 and Scheme AC using N-(3-{1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride: ESMS m/e: 663.2 (M+H)+.

後処理

  1. customPrepared by Procedure Q1 and Scheme AC

出典と根拠

ORDレコード
ord-89e2f635d64f4aada1ba55aacbac6206
出典データセット
uspto-grants-2006_06
特許番号
US07067534B1

関連ノート

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