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Acetamidine monohydrochloride → Diethyl 1-amino-1-methylmethyleneaminocarbonylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetamidine monohydrochloride | HCID 67170 | — |
| 反応物 | Phosphinecarboxylic acid, 1,1-diethoxy-, methyl ester, 1-oxide | HCID 170573 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Diethyl 1-amino-1-methylmethyleneaminocarbonylphosphonate | HCID 54283790 | — |
反応手順
A solution of 98 parts of diethyl methoxycarbonylphosphonate plus 47 parts of acetamidine hydrochloride in 1000 parts of anhydrous tetrahydrofuran can be refluxed for 8 hours and the solvent then removed under reduced pressure to give diethyl 1-amino-1-methylmethyleneaminocarbonylphosphonate. In a similar manner, starting with the appropriate alkoxycarbonylphosphonate and imino compounds, the following compounds can be prepared:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04066434 |
| 出典データセット | uspto-grants-1978_01 |
| ORD ID | ord-86fc9fb571a944cbafec8910d46961a9 |
| 出典メモ | uspto-grants-1978_01 |