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Chlorine monoxide → Ethyl 5-Hydroxy-4-Methyl-7-(3-Methyl-2-Octyl)-Coumarin-3-Propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorine monoxide | HCID 24646 | — |
| 反応物 | Diethyl 2-acetylglutarate | HCID 73915 | — |
| 反応物 | 5-(3-Methyloctan-2-yl)benzene-1,3-diol | HCID 258176 | — |
| 生成物 | Ethyl 5-Hydroxy-4-Methyl-7-(3-Methyl-2-Octyl)-Coumarin-3-Propionate | HCID 22765004 | — |
反応手順
A mixture of 262 g. (1.109 mole) of 5-(3-methyl-2-octyl)resorcinol, 283 g. (1.23 mole) of diethyl α-acetylglutarate, and 170 g. (1.11 mole) of phorphorus oxychloride protected from atmospheric mositure is stirred at room temperature for 12 days. The mixture is taken up in benzene-ether and the solution is washed several times with water, aqueous sodium bicarbonate, water and dried over anhydrous magnesium sulfate. After removal of the solvent, 441 g. of an oil is obtained, which solidifies on standing.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04066667 |
| 出典データセット | uspto-grants-1978_01 |
| ORD ID | ord-512ec0595d0e4f4f9427f04f33fd8ab3 |
| 出典メモ | uspto-grants-1978_01 |