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Ethanol → 1-(2-[6-Methylnicotinoyl]-1-methylvinylamino)-3-(p-[4-methoxybutoxy]-phenoxy)-propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 1-(6-Methylpyridin-3-yl)butane-1,3-dione | HCID 20212814 | — |
| 反応物 | HCID 20352683 | HCID 20352683 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 生成物 | 1-(2-[6-Methylnicotinoyl]-1-methylvinylamino)-3-(p-[4-methoxybutoxy]-phenoxy)-propan-2-ol | HCID 70618683 | 89% |
反応手順
54.0 g of 1-(p-[4-methoxybutoxy]-phenoxy)-3-aminopropan-2-ol ##STR76## 37.3 g of 6-methylnicotinoyl-acetone ##STR77## 400 ml of ethanol and 0.1 ml of formic acid are heated to 50° for 1 hour and stirred at room temperature for a further 20 hours. Filtration gives 61.3 g of 1-(2-[6-methylnicotinoyl]-1-methylvinylamino)-3-(p-[4-methoxybutoxy]-phenoxy)-propan-2-ol ##STR78## Melting point: 143°-145°. A further 15.0 g of the same substance can be obtained from the filtrate. Yield: 89% of theory.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04066768 |
| 出典データセット | uspto-grants-1978_01 |
| ORD ID | ord-e803bd29ad03488d9c7084cea1930d69 |
| 出典メモ | uspto-grants-1978_01 |