Sodium ethoxide → 4-(4-n-Heptylpyrimid-2-yl)-benzoic acid

HRID 1833716ノート

反応式

HRID 1833716 の反応式
Cl.[CH2:2]([O:4][C:5](=[O:15])[C:6]1[CH:11]=[CH:10][C:9]([C:12](=[NH:14])[NH2:13])=[CH:8][CH:7]=1)[CH3:3].[CH2:16]([C:23](=[CH:26]OCC)C=O)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[CH3:30]C[O-].[Na+]>CO>[CH2:2]([O:4][C:5](=[O:15])[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:23]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:26]=[CH:30][N:14]=2)=[CH:8][CH:7]=1)[CH3:3].[CH2:17]([C:16]1[CH:23]=[CH:26][N:13]=[C:12]([C:9]2[CH:8]=[CH:7][C:6]([C:5]([OH:4])=[O:15])=[CH:11][CH:10]=2)[N:14]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:30]

参加物

6

反応物 3

HCID 2723922Sodium ethoxideHCID 12710118Benzoic acid, 4-(aminoiminomethyl)-, ethyl ester, hydrochloride (1:1)HCID 542398243-Ethoxy-2-heptylacrolein

生成物 2

HCID 203796744-(4-n-Heptylpyrimid-2-yl)-benzoic acidHCID 543719414(4-n-Heptylpyrimid-2-yl)-benzoic acid ethyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A suspension of 0.1 mole of 4-amidino-benzoic acid ethyl ester hydrochloride, 0.1 mole of 2-n-heptyl-3-ethoxy-acrolein and 0.14 mole of sodium ethylate in 100 ml. of methanol is stirred overnight at room temperature under an atmosphere of nitrogen. After the usual work up and separation into basic and acidic fractions, there is obtained 4(4-n-heptylpyrimid-2-yl)-benzoic acid ethyl ester and 4-(4-n-heptylpyrimid-2-yl)-benzoic acid.

後処理

  1. customAfter the usual work up and separation into basic and acidic fractions

出典と根拠

ORDレコード
ord-02baf3ecd7674999909516370f1fd164
出典データセット
uspto-grants-1978_01
特許番号
US04066570

反応ノート

読み込み中…