Chloroacetyl isocyanate → N-(Chloroacetyl)-5-ethoxy-3-oxo-1,2,4-thiadiazole-2(3H)-carboxamide
反応式
[Cl:1][CH2:2][C:3]([N:5]=[C:6]=[O:7])=[O:4].[OH:8][C:9]1[N:13]=[C:12]([O:14][CH2:15][CH3:16])[S:11][N:10]=1>C1C=CC=CC=1>[Cl:1][CH2:2][C:3]([NH:5][C:6]([N:10]1[C:9](=[O:8])[N:13]=[C:12]([O:14][CH2:15][CH3:16])[S:11]1)=[O:7])=[O:4]参加物
4
反応条件
- 温度
- 20 °C
実験手順
31.5 g of α-chloroacetyl isocyanate were added dropwise to a solution of 18.98 g of 3-hydroxy-5-ethoxy-1,2,4-thiadiazole in 200 ml of benzene and after stirring the mixture for 17 hours at 20° C, it was vacuum filtered. The recovered crystals were dried to obtain 20 g of 2-(N-α-chloroacetylcarbamoyl)-5-ethoxy-1,2,4-thiadiazole-3-one melting at 132° C.
後処理
- filtrationfiltered
- customThe recovered crystals were dried
出典と根拠
- ORDレコード
- ord-abec7180f484464fbcf5172e68d0501e
- 出典データセット
- uspto-grants-1978_01
- 特許番号
- US04067720
反応ノート
読み込み中…