関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Pyridazine-3-carboxylic acid | HCID 269369 | — |
| 溶媒 | P-Cymene | HCID 7463 | — |
| 生成物 | (+/-) 3-alpha-Hydroxybenzylpyridazine | HCID 10397539 | 18.6% |
反応手順
Pyridazine-3-carboxylic acid [prepared as described by Leanza, Becker and Rogers, J.A.C.S., 75, 4086 (1953); 18.6 g.] was mixed with benzaldehyde (44 g.) and p-cymene (360 ml.) and decarboxylated by heating for 3 hours at 135° C. The hot solution was then filtered, cooled and the precipitate collected to give (±) 3-α-hydroxybenzylpyridazine (5.2 g.), m.p. 130°-135° C., in the form of fawn coloured needles.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04067723 |
|---|
| 出典データセット | uspto-grants-1978_01 |
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| ORD ID | ord-e92ba4ad06404f609a6584063ce73fb4 |
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| 出典メモ | uspto-grants-1978_01 |
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