Ethanol → 3-Ethoxy-7-chloro-benzo-1,2,4-triazine

HRID 1834023ノート

反応式

HRID 1834023 の反応式
Cl[C:2]1[N:3]=[N:4][C:5]2[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:6]=2[N:7]=1.[C-]#N.[Na+].[CH2:16]([OH:18])[CH3:17]>>[CH2:16]([O:18][C:2]1[N:3]=[N:4][C:5]2[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:6]=2[N:7]=1)[CH3:17]

参加物

4

反応物 3

HCID 702EthanolHCID 8929Sodium CyanideHCID 205554783,7-Dichloro-1,2,4-benzotriazine

生成物 1

HCID 213882453-Ethoxy-7-chloro-benzo-1,2,4-triazine

実験手順

A suspension of 20.2 g (0.1 mole) of 3,7-dichlorobenzo-1,2,4-triazine and 12.2 g (0.25 mole) of sodium cyanide in 200 ml of ethanol was boiled under reflux for 2 hours. The salts were filtered off and the filtrate was evaporated in vacuo. The residue was stirred with water and cooled in ice for some time. The crystallized mass was filtered off and recrystallized from wash benzine. 17.6 g, that is to say 84% of theory, of 3-ethoxy-7-chloro-benzo-1,2,4-triazine with a melting point of 90°-92° C were obtained.

後処理

  1. temperatureunder reflux for 2 hours
  2. filtrationThe salts were filtered off
  3. customthe filtrate was evaporated in vacuo
  4. temperaturecooled in ice for some time
  5. filtrationThe crystallized mass was filtered off
  6. customrecrystallized
  7. washfrom wash benzine

出典と根拠

ORDレコード
ord-34c55ef53e50409ea70f87a65c8960be
出典データセット
uspto-grants-1978_01
特許番号
US04067981

反応ノート

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