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2-(4-Aminobutyl)pyridin-3-amine → 3-Chloro-2-(4-aminobutyl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(4-Aminobutyl)pyridin-3-amine | HCID 13350838 | — |
| 反応物 | Hydrochloride sodium nitrite | HCID 86602196 | — |
| 生成物 | 3-Chloro-2-(4-aminobutyl)pyridine | HCID 20195970 | — |
反応手順
a. Reaction of 3-amino-2-(4-aminobutyl)pyridine with sodium nitrite/hydrochloric acid and treatment of the resultant diazonium salt with cuprous chloride yields 3-chloro-2-(4-aminobutyl)pyridine. By a similar procedure employing cuprous bromide and hydrobromic acid 3-bromo-2-(4-aminobutyl)-pyridine may be produced and when the diazonium salt is treated with sulphuric acid the product is 3-hydroxy-2-(4-aminobutyl) pyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04067984 |
| 出典データセット | uspto-grants-1978_01 |
| ORD ID | ord-0bdef5f8bd3f47799078494fcdefd1a8 |
| 出典メモ | uspto-grants-1978_01 |