Dichloromethane → HCID 70617081、化合物

HRID 1834072ノート

反応式

HRID 1834072 の反応式
Cl[CH2:2]Cl.[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6].O.S([O-])([O-])(=O)=O.[Mg+2]>C(N(CC)CC)C>[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6].[CH2:14]([N:11]([CH2:10][CH3:29])[CH2:12][CH3:2])[CH3:13]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 7061048122202-75-1

生成物 1

HCID 70617081HCID 70617081、化合物

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To 100 ml. of dichloromethane were added 4.2 g. of cephaloglycin monohydrate, 3.0 g. of anhydrous magnesium sulfate, and 2.1 ml. of triethylamine and after stirring the mixture for one hour at room temperature, magnesium sulfate was filtered off to provide a dichloromethane solution of cephaloglycin triethylamine salt. The solution was cooled to -30° C. and then 1.75 g. of 4-oxo-4H-thiopyran-3-carbonyl chloride and 2.1 ml. of triethylamine were added to the solution followed by stirring for one hour.

後処理

  1. filtrationmagnesium sulfate was filtered off

出典と根拠

ORDレコード
ord-0fddaa58609e4d1bb846840700c6665a
出典データセット
uspto-grants-1978_01
特許番号
US04068074

反応ノート

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