Potassium Iodide → 4-Methoxy-4-methylpiperidine hydrochloride
反応式
[Cl:1]CCCC(C1C=CC(F)=CC=1)=O.[CH3:14][C:15]1([O:21][CH3:22])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.[I-].[K+]>C1(C)C=CC=CC=1>[ClH:1].[CH3:14][C:15]1([O:21][CH3:22])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1参加物
5
実験手順
A solution of 20.1 g (0.1 m) of gamma-chloro-p-fluorobutyrophenone, 30 g (0.2 m) of 4-methyl-4-methoxy-piperidine and 0.1 g. of potassium iodide in 150 ml of toluene is heated in a glass autoclave for 15 hours at 100°-110° C. The KI and the 4-methyl-4-methoxy-piperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation under a vacuum on a steam bath. The obtained base is dissolved in ether and the hydrochloride is precipitated with alcoholic HCl. The reaction product is purified by recrystallization from ethanol-ether. Yield 22 g. Melting point 182° C.