Methylamine → N-cyano-N'-methyl-N"-[2-(2-pyrimidylmethylthio)ethyl]guanidine

反応式

ClC[C:3]1[N:8]=[CH:7]C=[CH:5][N:4]=1.C1(=O)[N:13](C(S)C)C(=O)C2=CC=CC=C12.[NH2:23][CH2:24][CH2:25][S:26][CH2:27][C:28]1[N:33]=[CH:32][CH:31]=[CH:30][N:29]=1.CN>>[C:5]([NH:4][C:3]([NH:8][CH3:7])=[N:23][CH2:24][CH2:25][S:26][CH2:27][C:28]1[N:29]=[CH:30][CH:31]=[CH:32][N:33]=1)#[N:13]

参加物

反応物 4

HCID 6329Methylamine

HCID 128773712-(Chloromethyl)pyrimidine

HCID 202424852-[(2-Aminoethyl)thiomethyl]pyrimidine

HCID 214047132-(1-Sulfanylethyl)isoindole-1,3-dione

生成物 1

HCID 178484995N-cyano-N'-methyl-N"-[2-(2-pyrimidylmethylthio)ethyl]guanidine

実験手順

Reacting 2-chloromethylpyrimidine with phthalimidoethanethiol by the procedure of Example 1(i)(b) and then reacting the resulting 2-[(2-aminoethyl)thiomethyl]-pyrimidine with dimethyl-N-cyanoimidodithiocarbonate and methylamine by the procedure of Example 3(d) gives N-cyano-N'-methyl-N"-[2-(2-pyrimidylmethylthio)ethyl]-guanidine.