Ethyl formate → HCID 21515920、化合物

反応式

[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:21](OCC)=[O:22]>>[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH:16][CH:21]=[O:22])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

反応物 2

HCID 8025Ethyl formate

HCID 203722482-(alpha,alpha,beta,beta-Tetrafluorophenethyl)benzylamine

生成物 1

HCID 21515920HCID 21515920、化合物

実験手順

2-(α, α, β, β-Tetrafluorophenethyl)benzylamine, 1.4 g. (0.005 mole), in 100 ml. of ethyl formate, is stirred and heated to refluxing for about 20 hours. Evaporation of the solution to dryness and trituration of the residual solid with petroleum ether gives N-[2-(α, α, β, β-tetrafluorophenethyl)benzyl]formamide, m.p. 61°-75° C.

後処理

temperatureheated
temperatureto refluxing for about 20 hours
customEvaporation of the solution to dryness and trituration of the residual solid with petroleum ether

出典と根拠

ORDレコード: ord-9e83aca5fc994393a6ff79eda389d245
出典データセット: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04071570

反応ノート

読み込み中…

参加物