Acetone → 2-(alpha,alpha,beta,beta-Tetrafluorophenethyl)phenylacetonitrile

HRID 1834861ノート

反応式

HRID 1834861 の反応式
[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Br)([F:12])[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([F:5])[F:4].[C-:21]#[N:22].[K+].CC(C)=O>O>[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][C:21]#[N:22])([F:12])[C:3]([F:5])([F:4])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 180AcetoneHCID 9032Potassium CyanideHCID 203722852-(alpha,alpha,beta,beta-Tetrafluorophenethyl)benzyl bromide

生成物 1

HCID 203722272-(alpha,alpha,beta,beta-Tetrafluorophenethyl)phenylacetonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-(α,α,β,β-Tetrafluorophenylethyl)benzyl bromide, 3.5 g. (0.01 mole), and 2.0 g. (0.0308 mole) of potassium cyanide are dissolved in 35 ml. of acetone - 5 ml. of water and the solution is heated to refluxing for about 18 hours. The organic phase is separated, acetone is distilled under reduced pressure, and the residual oil is dissolved in benzene. Evaporation of the washed and dried benzene extract under reduced pressure leaves the product as the residual brown oil.

後処理

  1. temperatureto refluxing for about 18 hours
  2. customThe organic phase is separated
  3. distillationacetone is distilled under reduced pressure
  4. dissolutionthe residual oil is dissolved in benzene
  5. customEvaporation of the
  6. washwashed
  7. extractiondried benzene extract under reduced pressure
  8. customleaves the product as the residual brown oil

出典と根拠

ORDレコード
ord-d4fa508d8c454ce1be8e3d8d21d8b975
出典データセット
uspto-grants-1978_01
特許番号
US04071570

反応ノート

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