17beta,19-Dihydroxy-1alpha,7alpha-dimethyl-4-androsten-3-one → 1alpha,7alpha-Dimethyl-4-androstene-3,17,19-trione

HRID 1834944ノート

反応式

HRID 1834944 の反応式
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:19]([CH2:20][CH2:21][C@:3]12[CH3:4])[C@:16]1([CH2:17][OH:18])[C:11](=[CH:12][C:13](=[O:23])[CH2:14][C@@H:15]1[CH3:22])[CH2:10][C@H:9]3[CH3:24].CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[CH3:22][C@@H:15]1[C@@:16]2([CH:17]=[O:18])[C:11]([CH2:10][C@@H:9]([CH3:24])[C@@H:8]3[C@@H:19]2[CH2:20][CH2:21][C@@:3]2([CH3:4])[C@H:5]3[CH2:6][CH2:7][C:2]2=[O:1])=[CH:12][C:13](=[O:23])[CH2:14]1

参加物

4

反応物 2

HCID 7058545317beta,19-Dihydroxy-1alpha,7alpha-dimethyl-4-androsten-3-oneHCID 131709961Jones' reagent

生成物 1

HCID 538793401alpha,7alpha-Dimethyl-4-androstene-3,17,19-trione

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

To a solution of 17β,19-dihydroxy-1α,7α-dimethyl-4-androsten-3-one in acetone at 20° C. is added two equivalents of Jones Reagent and the mixture stirred for 30 minutes. The acetone layer is poured onto water with vigorous stirring. The crystals are removed by suction filtration and air dried. Crystallization from an acetone-hexane solution yields 1α,7α-dimethyl-4-androstene-3,17,19-trione.

後処理

  1. customThe crystals are removed by suction filtration and air
  2. customdried
  3. customCrystallization from an acetone-hexane solution

出典と根拠

ORDレコード
ord-04ef2f3a3ccf481b9aa6bcead4125467
出典データセット
uspto-grants-1978_01
特許番号
US04071624

反応ノート

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