2-(3,5-Bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyrid-3-yl)-N,2-dimethylpropanamide → 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-fluoro-2-methyl-phenyl)-6-iodo-pyridin-3-yl]-N-methyl-isobutyramide
反応式
FC(F)(F)C1C=C(C(C)(C)C(N(C2C=NC([I:31])=CC=2C2C=CC=CC=2Cl)C)=O)C=C(C(F)(F)F)C=1.[F:36][C:37]([F:71])([F:70])[C:38]1[CH:39]=[C:40]([C:48]([CH3:69])([CH3:68])[C:49]([N:51]([C:53]2[CH:54]=[N:55][C:56](Cl)=[CH:57][C:58]=2[C:59]2[CH:64]=[CH:63][C:62]([F:65])=[CH:61][C:60]=2[CH3:66])[CH3:52])=[O:50])[CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1>>[F:36][C:37]([F:71])([F:70])[C:38]1[CH:39]=[C:40]([C:48]([CH3:69])([CH3:68])[C:49]([N:51]([C:53]2[CH:54]=[N:55][C:56]([I:31])=[CH:57][C:58]=2[C:59]2[CH:64]=[CH:63][C:62]([F:65])=[CH:61][C:60]=2[CH3:66])[CH3:52])=[O:50])[CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1参加物
3
反応物 2
生成物 1
実験手順
The title compound is prepared according to the procedure described above for the preparation of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-chloro-phenyl)-6-iodo-pyridin-3-yl]-N-methyl-isobutyramide (Example 25) using 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide instead of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide.