Hydrogen Peroxide → Methyl 3-hydroxyquinoline-8-carboxylate
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[N:13]=[CH:12][CH:11]=[CH:10]2)=[O:4].OO.C([O-])(O)=[O:18].[Na+]>CC(O)=O>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[N:13]=[CH:12][C:11]([OH:18])=[CH:10]2)=[O:4]参加物
5
実験手順
To a solution of the intermediate 8-Quinolinecarboxylic acid methyl ester (2.89 mmol) in AcOH (4 ml) was added 30% H2O2 (0.6 ml). The reaction mixture was heated at 85 degrees for 7.5 hr. The reaction mixture was treated with sat NaHCO3, and extracted six times with CHCl3. Organic layer was dried over anhydrous MgSO4, and concentrated. Crude residue was triturated with CHCl3/Toluene to provide compound 313 (256 mg, 44%, in 2 steps).
後処理
- temperatureThe reaction mixture was heated at 85 degrees for 7.5 hr
- extractionextracted six times with CHCl3
- dry with materialOrganic layer was dried over anhydrous MgSO4
- concentrationconcentrated
- customCrude residue was triturated with CHCl3/Toluene
出典と根拠
- ORDレコード
- ord-09cfc274201d4601830cae76f9331b9a
- 出典データセット
- uspto-grants-2004_08
- 特許番号
- US06770648B2
反応ノート
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