Ethyl 2-[4-(3-bromophenoxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate → Ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)benzimidazole-5-carboxylate

HRID 1835572

反応式

HRID 1835572 の反応式
BrC1C=C(C=CC=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:16]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[C:15]3[CH:23]=[CH:24][C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:26][C:14]=3[N:13]=2)=[CH:8][CH:7]=1.Cl.OC1C=CC(C(=N)OC)=CC=1>CO>[CH:17]1([N:16]2[C:15]3[CH:23]=[CH:24][C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:26][C:14]=3[N:13]=[C:12]2[C:9]2[CH:10]=[CH:11][C:6]([OH:5])=[CH:7][CH:8]=2)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1

参加物

4

反応物 2

HCID 9914616Ethyl 2-[4-(3-bromophenoxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylateHCID 135889529Methyl 4-hydroxybenzimidate hydrochloride

生成物 1

HCID 135486203Ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)benzimidazole-5-carboxylate収率 143.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Ethyl 3-amino-4-cyclohexylaminobenzoate (130 g) obtained in Example 1, Step 3, and methyl 4-hydroxybenzimidate hydrochloride (139 g) were added to methyl alcohol (1500 ml), and the mixture was refluxed under heating for 4 hr. The reaction mixture was allowed to cool and the precipitated crystals were collected by filtration to give the title compound (131 g, yield 72%).

後処理

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 4 hr
  3. temperatureto cool
  4. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-50c68412279143dfbc48f14b6af631ce
出典データセット
uspto-grants-2004_08
特許番号
US06770666B2

関連ノート

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