Water → HCID 2794448、化合物

HRID 1835687ノート

反応式

HRID 1835687 の反応式
[C:1](OC(C)(C)C)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([O:21][CH3:22])[CH:20]=1)[NH2:17].CS(O)(=O)=O.O>C1(C)C(C)=CC=CC=1>[CH3:22][O:21][C:19]1[CH:20]=[C:14]([O:13][CH3:12])[CH:15]=[C:16]2[C:18]=1[C:3]([CH3:5])=[CH:2][C:1](=[O:6])[NH:17]2

参加物

6

反応物 4

HCID 962WaterHCID 6395Methanesulfonic AcidHCID 15538Tert-butyl acetoacetateHCID 663013,5-Dimethoxyaniline

生成物 1

HCID 2794448HCID 2794448、化合物

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

反応条件

温度
125 °C

実験手順

tert-Butyl acetoacetate (1.58 g) was heated to 120° C. and 3,5-dimethoxyaniline (1.53 g) dissolved in xylene (4 ml) was added The mixture was heated at 120-130° C. for 20 minutes and then cooled to room temperature. Methanesulfonic acid (2 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. Water (40 ml) was added and the precipitate filtered and dried. Yield 1.31 g (60%).

後処理

  1. additionwas added The mixture
  2. temperaturecooled to room temperature
  3. filtrationthe precipitate filtered
  4. customdried

出典と根拠

ORDレコード
ord-474de6f4f16d4f82961aa3bac26dbc04
出典データセット
uspto-grants-2004_08
特許番号
US06774103B1

反応ノート

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