化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → Spiro[indoline-3,3'-perhydroazepin]-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N-benzyl-4-(1H-indol-3-yl)butanamide | HCID 3499346 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | n-Benzyl-4-(3-indolyl)-butanamine | HCID 23500776 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Spiro[indoline-3,3'-perhydroazepin]-2-one | HCID 23500655 | — |
反応手順
N-Benzyl-4-(3-indolyl)-butanamine. Lithium aluminum hydride (4.8 g) was added to a solution of N-benzyl-3-indolebutanamide (18.73 g) in dry THF (200 mL) at nitrogen atmosphere and at 0° C. After stirring at reflux for 15 h and work-up with sodium hydroxide the title compound was obtained as pale yellow crystals (16.4 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06774132B1 |
| 出典データセット | uspto-grants-2004_08 |
| ORD ID | ord-8087d3aa0acb4f2da5cae3a17314526a |
| 出典メモ | uspto-grants-2004_08 |