Hydrochloric Acid → Spiro[indoline-3,3'-perhydroazepin]-2-one
反応式
[CH2:1]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[NH:15][C:14]1=[O:22])C1C=CC=CC=1.Cl>CS(C)=O.CO>[NH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][C:13]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:15][C:14]2=[O:22])[CH2:1]1参加物
5
反応条件
- 温度
- 0 °C
実験手順
3-(4-(Benzylamino)-butyl)-indolin-2-one. Conc hydrochloric acid (90 mL) was added to a solution of the compound from the previous step in DMSO (38 mL) and MeOH (8 mL). After stirring for 30 min at 0° C. and 30 min at room temperature the mixture was poured onto ice followed by extractive work-up. The title compound was obtained as a crude orange oil (16.2 g).
後処理
- additionwas poured onto ice
出典と根拠
- ORDレコード
- ord-2c4c367239604fd79b0cc663e9683aa6
- 出典データセット
- uspto-grants-2004_08
- 特許番号
- US06774132B1
反応ノート
読み込み中…