Potassium Carbonate → methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate

HRID 1836160

反応式

HRID 1836160 の反応式
Cl[C:2]1[C:3]2[N:16]([CH3:17])[N:15]=[C:14]([CH2:18][CH2:19][CH3:20])[C:4]=2[N:5]=[C:6]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[N:7]=1.[Cl:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][C:29]=1[O:30][CH3:31])[CH2:25][NH2:26].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][C:29]=1[O:30][CH3:31])[CH2:25][NH:26][C:2]1[C:3]2[N:16]([CH3:17])[N:15]=[C:14]([CH2:18][CH2:19][CH3:20])[C:4]=2[N:5]=[C:6]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[N:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 7380383-Chloro-4-methoxybenzylamineHCID 11150640methyl 3-[7-chloro-1-methyl-3-propyl-1H-pyrazolo[4,3-d)pyrimidin-5-yl]propionate

生成物 1

HCID 11774810methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate収率 105.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3 g of methyl 3-[7-chloro-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate and 1.9 g of 3-chloro-4-methoxybenzylamine (“A”) in 50 ml of dimethylformamide (DMF) are stirred at 60° for 12 hours in the presence of potassium carbonate. After filtration, the solvent is removed and the mixture is worked up in the customary manner. 4.6 g of methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate are obtained as a colourless oil.

後処理

  1. filtrationAfter filtration
  2. customthe solvent is removed

出典と根拠

ORDレコード
ord-7a6d2041face4b23bc606ecb3a72658d
出典データセット
uspto-grants-2004_08
特許番号
US06777419B1

関連ノート

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