反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[F:17][CH:18]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:19](O)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH:11]2[CH2:16][CH2:15][N:14]([CH2:19][CH:18]([F:17])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:13][CH2:12]2)(=[O:9])=[O:10])=[CH:6][CH:7]=1参加物
3
実験手順
4-(4-Bromophenylsulphonyl)piperidine (0.7 g, 2.3 mmol) was reacted with α-fluorophenylacetic acid (0.53 g, 3.45 mmol) in a similar manner as described for Example 13, Steps a and b, to give the required product as a colourless solid, 0.56 g (58%), m.p. 126-127° C. (EtOAc-pet. ether 60-80°). δH (400 MHz, CDCl3) 1.70-1.77 (2H, m), 2.00-2.03 (2H, m), 2.13-2.20 (2H, m), 2.57-2.69 (1H, m), 2.83-2.93 (2H, s), 3.04-3.18 (2H, m), 5.51-5.65 (1H, m), 7.28-7.39 (5H, m), 7.70-7.75 (4H, m).
出典と根拠
- ORDレコード
- ord-e18ab72c581a4f6aac166f20fc7bde83
- 出典データセット
- uspto-grants-2004_08
- 特許番号
- US06777430B2
関連ノート
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