4-Phenylbenzoyl chloride → 4-[3-(4-Phenylbenzamidyl)benzoyl]-1-methylpiperidine

反応式

[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:6].[C:17]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:22]=[CH:21][C:20]([C:23](Cl)=[O:24])=[CH:19][CH:18]=1>>[C:26]1([C:17]2[CH:18]=[CH:19][C:20]([C:23]([NH:1][C:2]3[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=3)[C:5]([CH:7]3[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12]3)=[O:6])=[O:24])=[CH:21][CH:22]=2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

参加物

反応物 2

HCID 841514-Phenylbenzoyl chloride

HCID 101306514-[3-Aminobenzoyl]-1-methylpiperidine

生成物 1

HCID 693536994-[3-(4-Phenylbenzamidyl)benzoyl]-1-methylpiperidine収率 34%

実験手順

Beginning with 4-[3-aminobenzoyl]-1-methylpiperidine (50 mg, 0.229 mmol) and 4-biphenylcarbonyl chloride (150 mg, 0.687 mmol), 30.8 mg (34%) of the title compound were recovered.

出典と根拠

ORDレコード: ord-5ae14f0cb2864eb185e8781f4b3cb475
出典データセット: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06777428B1

反応ノート

読み込み中…