2,3,4-Trifluorobenzoyl chloride → HCID 69355841、化合物

反応式

[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:6].[F:17][C:18]1[C:26]([F:27])=[C:25]([F:28])[CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>>[F:17][C:18]1[C:26]([F:27])=[C:25]([F:28])[CH:24]=[CH:23][C:19]=1[C:20]([NH:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12]1)=[O:6])=[O:21]

参加物

反応物 2

HCID 27340222,3,4-Trifluorobenzoyl chloride

HCID 101306514-[3-Aminobenzoyl]-1-methylpiperidine

生成物 1

HCID 69355841HCID 69355841、化合物

実験手順

Beginning with 4-[3-aminobenzoyl]-1-methylpiperidine (25 mg, 0.115 mmol) and 2,3,4-trifluorobenzoyl chloride (29 μL, 0.229 mmol) and mixing for 24 h, 46.4 mg (>100%) of the title compound were recovered.

後処理

additionmixing for 24 h
custom46.4 mg (>100%) of the title compound were recovered

出典と根拠

ORDレコード: ord-69a2ffb4a5dc4ff8b5c608101b12878a
出典データセット: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06777428B1

反応ノート

読み込み中…