{4-(Benzyloxy)-3-[(4-fluorophenyl)sulphonyl]phenyl}methanol → 4-(Benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzaldehyde
反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:10]=1[S:17]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+4].[O-2]>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[O:16])=[CH:11][C:10]=1[S:17]([C:20]1[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=1)(=[O:19])=[O:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
2.1 g (5.64 mmol) of {4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]phenyl}methanol (Example V) are dissolved in 25 ml of dichloromethane. At room temperature, 4.9 g (56.39 mmol) of manganese(IV) oxide are added. The mixture is stirred at room temperature overnight. The reaction mixture is then filtered through Celite and the solvent is removed under reduced pressure. This gives 1.82 g (86% of theory) of 4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzaldehyde.