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Potassium Carbonate → Ethyl(4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)acetate

HRID 1836556
ノート
印刷プレビュー

反応式

HRID 1836556 の反応式
[CH2:1]([O:8][C:9]1[CH:24]=[CH:23][C:12]([CH2:13][C:14]2[C:19]([CH3:20])=[CH:18][C:17]([OH:21])=[CH:16][C:15]=2[CH3:22])=[CH:11][C:10]=1[S:25]([C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)(=[O:27])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:41]([O:44][CH2:45][CH2:46]Br)(=[O:43])[CH3:42].[Cl-].[NH4+]>CN(C)C=O>[CH2:45]([O:44][C:41](=[O:43])[CH2:42][O:21][C:17]1[CH:18]=[C:19]([CH3:20])[C:14]([CH2:13][C:12]2[CH:23]=[CH:24][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[C:10]([S:25]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)(=[O:26])=[O:27])[CH:11]=2)=[C:15]([CH3:22])[CH:16]=1)[CH3:46]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 135641-Acetoxy-2-bromoethaneHCID 25517Ammonium ChlorideHCID 234996174-{4-(Benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenol

生成物 1

HCID 23499607Ethyl(4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)acetate

試薬・触媒・溶媒 1

HCID 6228
Dimethylformamide
溶媒

実験手順

85 mg (0.18 mmol) of 4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenol (Example X) are dissolved in 2 ml of dimethylformamide. 30 mg (0.21 mmol) of potassium carbonate and 33 mg (0.20 mmol) of bromoethyl acetate are added. The mixture is stirred at room temperature overnight. Saturated ammonium chloride solution is then added, and the mixture is extracted three times with diethyl ether. The combined organic phases are washed three times with water, dried with sodium sulphate and concentrated under reduced pressure. This gives 80 mg (96.5% of theory) of ethyl (4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)acetate.

後処理

  1. extractionthe mixture is extracted three times with diethyl ether
  2. washThe combined organic phases are washed three times with water
  3. dry with materialdried with sodium sulphate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-e2e4ab9149f448d199757c93ed68153c
出典データセット
uspto-grants-2004_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06777442B2

反応ノート

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