7-piperazinyl-2-(pyridin-2-yl)methyl-2H-phthalazin-1-one → 2-(Pyridin-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]piperazin-1-yl]-2H-phthalazin-1-one

HRID 1836845ノート

反応式

HRID 1836845 の反応式
[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[N:27]1([C:33]2[CH:42]=[C:41]3[C:36]([CH:37]=[N:38][N:39]([CH2:44][C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][N:46]=4)[C:40]3=[O:43])=[CH:35][CH:34]=2)[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[N:46]1[CH:47]=[CH:48][CH:49]=[CH:50][C:45]=1[CH2:44][N:39]1[N:38]=[CH:37][C:36]2[C:41](=[CH:42][C:33]([N:27]3[CH2:32][CH2:31][N:30]([CH2:23][CH2:22][CH2:21][C:7]4([C:5](=[O:6])[NH:4][CH2:3][C:2]([F:26])([F:25])[F:1])[C:20]5[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=5[O:14][C:13]5[C:8]4=[CH:9][CH:10]=[CH:11][CH:12]=5)[CH2:29][CH2:28]3)=[CH:34][CH:35]=2)[C:40]1=[O:43]

参加物

3

反応物 2

HCID 221802937-piperazinyl-2-(pyridin-2-yl)methyl-2H-phthalazin-1-oneHCID 221805833-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl bromide

生成物 1

HCID 221804552-(Pyridin-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]piperazin-1-yl]-2H-phthalazin-1-one

実験手順

Step (b) of Example 92 was repeated, except that the compound prepared in step (b) of Example 114 and the compound prepared in step (c) of Example 143 were used as the starting compounds. Thus, the title compound was obtained.

出典と根拠

ORDレコード
ord-a40d9e1625fd4ebcb16a1195d112489d
出典データセット
uspto-grants-2004_08
特許番号
US06777414B1

反応ノート

読み込み中…