Dinitrofluorobenzene → N-(2,4-dinitrophenyl)-5-methyltryptamine

HRID 1837141ノート

反応式

HRID 1837141 の反応式
[CH3:1][C:2]1[CH:13]=[C:12]2[C:5]([NH:6][CH:7]=[C:8]2[CH2:9][CH2:10][NH2:11])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].[N+:19]([C:22]1[CH:27]=[C:26]([N+:28]([O-:30])=[O:29])[CH:25]=[CH:24][C:23]=1F)([O-:21])=[O:20]>O.C(O)C>[N+:19]([C:22]1[CH:27]=[C:26]([N+:28]([O-:30])=[O:29])[CH:25]=[CH:24][C:23]=1[NH:11][CH2:10][CH2:9][C:8]1[C:12]2[C:5](=[CH:4][CH:3]=[C:2]([CH3:1])[CH:13]=2)[NH:6][CH:7]=1)([O-:21])=[O:20]

参加物

6

反応物 3

HCID 6264DinitrofluorobenzeneHCID 157605-MethyltryptamineHCID 516892Sodium Bicarbonate

生成物 1

HCID 9881070N-(2,4-dinitrophenyl)-5-methyltryptamine収率 85%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

1 mMole of 5-metyltryptamine was dissolved in 100 ml of water and the pH was adjusted to pH 8.3 with 2.5 moles of sodium bicarbonate (NaHCO3), A 1.5% solution of 2,4-dinitrofluorobenzene in 200 ml ethanol was added and the mixture was stirred during 2 hours at room temperature. The desired product precipitates out, it is washed and dried. The product is obtained in 85% yield, and TLC (chloroform, silica-gel plates, reveals one yellow spot (Rf=0.8) which is well resolved from the starting materials under the same conditions.

後処理

  1. customThe desired product precipitates out
  2. washit is washed
  3. customdried
  4. customThe product is obtained in 85% yield, and TLC (chloroform, silica-gel plates

出典と根拠

ORDレコード
ord-a2fbf7e83c0d46b6a343e10fb89c8769
出典データセット
uspto-grants-2004_08
特許番号
US06780884B2

反応ノート

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