Water → Methyl 4-cyano-3-oxobutanoate
反応式
Br[CH2:2][C:3](=[O:9])[CH2:4][C:5]([O:7][CH3:8])=[O:6].[C-:10]#[N:11].[Na+].O>CO>[C:10]([CH2:2][C:3](=[O:9])[CH2:4][C:5]([O:7][CH3:8])=[O:6])#[N:11]参加物
5
実験手順
10 g of methyl 4-bromo-3-oxobutanoate is dissolved in 100 g of methanol. The resultant solution is cooled to 0° C. and a solution of 4 g of sodium cyanide in 100 g of methanol is added thereto. After completion of the addition, the mixture is warmed gradually to room temperature under stirring. Thereafter, the reaction mixture is poured into water, and extracted with ethyl acetate. The organic layer is washed with saturated brine, dried, concentrated to obtain methyl 4-cyano-3-oxobutanoate.
後処理
- additionAfter completion of the addition
- extractionextracted with ethyl acetate
- washThe organic layer is washed with saturated brine
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-8160c47d91384ffabfc53baa2984f0a9
- 出典データセット
- uspto-grants-2004_08
- 特許番号
- US06781009B2
反応ノート
読み込み中…