2-Methoxyethanol → 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-(2-methoxyethoxy)3-quinolinecarbonitrile

反応式

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH:11][C:12]1[C:21]2[C:16](=[CH:17][C:18](F)=[C:19]([O:22][CH2:23][CH3:24])[CH:20]=2)[N:15]=[CH:14][C:13]=1[C:26]#[N:27].[CH3:28][O:29][CH2:30][CH2:31][OH:32]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:32][CH2:31][CH2:30][O:29][CH3:28])=[C:19]([O:22][CH2:23][CH3:24])[CH:20]=2)[N:15]=[CH:14][C:13]=1[C:26]#[N:27]

参加物

反応物 2

HCID 80192-Methoxyethanol

HCID 115459364-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-fluoro-3-quinolinecarbonitrile

生成物 1

HCID 103442944-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-(2-methoxyethoxy)3-quinolinecarbonitrile

実験手順

Following the procedure used to prepare Example 17, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-fluoro-3-quinolinecarbonitrile (138 mg, 0.34 mmol) and 2-methoxyethanol provides 105 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-(2-methoxyethoxy)3-quinolinecarbonitrile, mp 215-217° C.

出典と根拠

ORDレコード: ord-133cb00d00c04b2c8e0f357c423a4782
出典データセット: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06780996B2

反応ノート

読み込み中…