4-Chloro-5-methylthieno[2,3-d]pyrimidine → 4-[2-Methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]-5-methylthieno[2,3-d]pyrimidine

HRID 1837471ノート

反応式

HRID 1837471 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8].Cl[C:25]1[C:26]2[C:33]([CH3:34])=[CH:32][S:31][C:27]=2[N:28]=[CH:29][N:30]=1>C(O)(C)C>[CH3:8][C:7]1[CH:6]=[CH:5][C:4]([NH:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[CH:13]=2)=[O:11])=[CH:3][C:2]=1[NH:1][C:25]1[C:26]2[C:33]([CH3:34])=[CH:32][S:31][C:27]=2[N:28]=[CH:29][N:30]=1

参加物

4

反応物 2

HCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidineHCID 17904941N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide

生成物 1

HCID 99121024-[2-Methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]-5-methylthieno[2,3-d]pyrimidine収率 25.4%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
88 °C

実験手順

N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide (0.056 g), 4-chloro-5-methylthieno[2,3-d]pyrimidine (Maybridge Chemical Company, Trevillet, Tintagel, Cornwall, PL34 0HW, GB; 0.037 g) and isopropanol (2 ml) and the reaction mixture was stirred and heated to 88° C. for 18 hours. The reaction mixture was cooled to ambient temperature and the precipitate was isolated and washed in turn with isohexane and diethyl ether. There was thus obtained the title compound (0.021 g); Mass: M+H+ 461.

後処理

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. customthe precipitate was isolated
  3. washwashed in turn with isohexane and diethyl ether

出典と根拠

ORDレコード
ord-9ee3689c8f5440d0a2f65b0cd3e41f3d
出典データセット
uspto-grants-2004_08
特許番号
US06784174B1

反応ノート

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