Water → 2-bromo-1-(2,3-dihydro-1H-inden-2-yl)ethan-1-one
反応式
[Br:1]Br.[C:3]([CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)(=[O:5])[CH3:4].O>CO>[Br:1][CH2:4][C:3]([CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5]参加物
5
実験手順
10 g of pure bromine are rapidly added at 0° C. to a solution of 10 g of 2-acetylindane in 150 ml of anhydrous methanol. After one hour at ambient temperature, 100 ml of water are added and the whole is stirred for 12 hours. After extracting twice with 200 ml of diethyl ether each time, and washing the organic phase with a sodium hydrogen carbonate solution and then with water, the expected product is dried over magnesium sulphate and concentrated.
後処理
- extractionAfter extracting twice with 200 ml of diethyl ether each time
- washwashing the organic phase with a sodium hydrogen carbonate solution
- dry with materialwith water, the expected product is dried over magnesium sulphate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-d2f3c070e3ad453590716dc0f62b1c51
- 出典データセット
- uspto-grants-2004_08
- 特許番号
- US06784183B2
反応ノート
読み込み中…