Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetate → Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl]-4-piperidyl]acetate

HRID 1837698ノート

反応式

HRID 1837698 の反応式
[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][C:13](=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.[H][H]>C(OCC)(=O)C.[C].[Pd]>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

5

反応物 2

HCID 22678611Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 22678708Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl]-4-piperidyl]acetate

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

2.6 g of ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetate and 380 mg of 10% palladium-carbon powder (water-containing product) were suspended in 20 ml of ethyl acetate. After replacing the atmosphere of a container with hydrogen, the mixture was stirred at room temperature under normal pressure for one hour. The reaction solution was filtered, and the filtrate was evaporated, to give the title compound as a yellow oil (quantitatively).

後処理

  1. filtrationThe reaction solution was filtered
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-dbcbbeefeab445ea88f19733d65a9076
出典データセット
uspto-grants-2004_08
特許番号
US06784192B2

反応ノート

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