Dimethylformamide → 2-(2-Methoxypyridin-3-yl)acetonitrile

HRID 1837702ノート

反応式

HRID 1837702 の反応式
[CH3:1][O:2][C:3]1[C:8]([CH2:9]Cl)=[CH:7][CH:6]=[CH:5][N:4]=1.[C-]#N.[Na+].[CH3:14][N:15](C=O)C>O>[CH3:1][O:2][C:3]1[C:8]([CH2:9][C:14]#[N:15])=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 149329453-(Chloromethyl)-2-methoxypyridine

生成物 1

HCID 226785372-(2-Methoxypyridin-3-yl)acetonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4 g of (2-methoxy-3-pyridyl)methyl chloride, 2.5 g of sodium cyanide and 10 ml of DMF were stirred under heating for 10 minutes. Water was added thereto, and the mixture was extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The drying agent was removed, and the solvent was evaporated. The residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1), to give 2.5 g of a colorless oil.

後処理

  1. temperatureunder heating for 10 minutes
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe drying agent was removed
  5. customthe solvent was evaporated
  6. customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1)

出典と根拠

ORDレコード
ord-f1231a14f7534ee4895c0a159a0db220
出典データセット
uspto-grants-2004_08
特許番号
US06784192B2

反応ノート

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