Triethylamine → 2-(2-Methoxypyridin-3-yl)acetaldehyde

HRID 1837705ノート

反応式

HRID 1837705 の反応式
[CH3:1][O:2][C:3]1[C:8]([CH2:9][CH2:10][OH:11])=[CH:7][CH:6]=[CH:5][N:4]=1.C(N(CC)CC)C.C(=O)(O)[O-].[Na+]>CS(C)=O>[CH3:1][O:2][C:3]1[C:8]([CH2:9][CH:10]=[O:11])=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 140623082-(2-Methoxy-3-pyridinyl)ethanol

生成物 1

HCID 226786312-(2-Methoxypyridin-3-yl)acetaldehyde収率 16.9%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

A solution of 2.7 g of pyridine-sulfur trioxide complex dissolved in DMSO was added dropwise at 20° C. or less to a solution of 1.2 g of 2-(2-methoxy-3-pyridyl)ethanol and 4.8 ml of triethylamine dissolved in DMSO. After stirring for 0.5 hour, a cooled sodium bicarbonate was added thereto, and the mixture was extracted with ethyl acetate. After drying over sodium sulfate, the solvent was evaporated. The residue was purified by silica gel chromatography (hexane:ethyl acetate=4:1), to give 200 mg of a yellow oil.

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialAfter drying over sodium sulfate
  3. customthe solvent was evaporated
  4. customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=4:1)

出典と根拠

ORDレコード
ord-c291d7359dc945199dd859cba9edd73b
出典データセット
uspto-grants-2004_08
特許番号
US06784192B2

反応ノート

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