Methanol → 1-[(2-Methoxy-3-pyridyl)methyl]-4-[2-(2-aminophenyl)-2-oxoethyl]piperidine

HRID 1837738ノート

反応式

HRID 1837738 の反応式
[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17](=[O:31])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH:24]C(=O)C(F)(F)F)[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.C(=O)([O-])[O-].[K+].[K+].CO>O>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH2:24])=[O:31])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

5

反応物 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 226786181-[(2-Methoxy-3-pyridyl)methyl]-4-[2-oxo-2-(2-trifluoroacetylaminophenyl)ethyl]piperidine

生成物 1

HCID 226784371-[(2-Methoxy-3-pyridyl)methyl]-4-[2-(2-aminophenyl)-2-oxoethyl]piperidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

150 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[2-oxo-2-(2-trifluoroacetylaminophenyl)ethyl]piperidine obtained in Example 63 and 141 mg of potassium carbonate were suspended in a mixed solvent of 3 ml of methanol and 3 ml of water, and the mixture was stirred at room temperature for one hour. The reaction solution was extracted with ethyl acetate, and the organic layer was washed with brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound as a yellow oil (quantitatively).

後処理

  1. extractionThe reaction solution was extracted with ethyl acetate
  2. washthe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-eefd2cbd4dc849369a64e71bdc1c7900
出典データセット
uspto-grants-2004_08
特許番号
US06784192B2

反応ノート

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