Trimethylsilyldiazomethane → HCID 69853620、化合物

HRID 1837860ノート

反応式

HRID 1837860 の反応式
[Si](C=[N+]=[N-])(C)(C)[CH3:2].[NH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([CH:17]([CH3:22])[CH2:18][C:19]([OH:21])=[O:20])=[CH:9]1>CO>[CH3:2][O:20][C:19](=[O:21])[CH2:18][C@H:17]([C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][CH:9]=1)[CH3:22]

参加物

4

反応物 2

HCID 167693TrimethylsilyldiazomethaneHCID 2738003-(1H-indol-3-yl)butanoic acid

生成物 1

HCID 69853620HCID 69853620、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-(1H-Indol-3-yl)-butanal (130 mg, 0.690 mmol) was dissolved in tert-butyl alcohol (27 mL) and 2-methyl-2-butene (4.7 mL) and subsequently was stirred for 10 min. To this solution was added an aqueous solution (4.7 mL) of NaClO2 (75 mg, 0.83 mmol) and NaH2PO4 (115 mg, 0.830 mmol) in one portion. The reaction mixture was stirred at room temperature for 12 h. The organics were removed by concentrating in vacuo. The residue was diluted with 10 mL of H2O, and adjusted to a neutral pH with 1M HCl. Extraction with EtOAc (3×10 mL), drying over Na2SO4, and concentration in vacuo provided 3-(1H-indol-3-yl)-butanoic acid. TMS-diazomethane was added dropwise to a solution of the crude 3-(1H-indol-3-yl)-butanoic acid in methanol (7 mL) until a yellow color persisted. The residual TMS-diazomethane was quenched by the dropwise addition of acetic acid until the yellow color disappeared. The reaction was then treated with an excess of saturated aqueous sodium bicarbonate, extracted with Et2O (3×20 ml), dried over Na2SO4 and purified by silica gel chromatography (20:80 EtOAc/hexanes to provide (R)-3-(1H-indol-3-yl)-butyric acid methyl ester. [α]D=−7.6 (c=1.0 benzene); reported rotation for (S)-3-(1H-indol-3-yl)-butyric acid methyl ester [α]D=+10.9 (c=2.12, benzene).

後処理

  1. customThe residual TMS-diazomethane was quenched by the dropwise addition of acetic acid until the yellow color
  2. additionThe reaction was then treated with an excess of saturated aqueous sodium bicarbonate
  3. extractionextracted with Et2O (3×20 ml)
  4. dry with materialdried over Na2SO4
  5. custompurified by silica gel chromatography (20:80 EtOAc/hexanes

出典と根拠

ORDレコード
ord-fc1043b33c764d4494a24b8d15b6d39d
出典データセット
uspto-grants-2004_08
特許番号
US06784323B2

反応ノート

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