Dichloromethane → HCID 54440811、化合物

HRID 1837927ノート

反応式

HRID 1837927 の反応式
O=[C:2]([CH3:11])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[O:10].[C:12](C=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:14][CH2:15][CH3:16])=[O:13].[CH2:37](Cl)Cl>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9](=[O:10])[CH3:37])[CH3:16]

参加物

4

反応物 3

HCID 6344Dichloromethane2 回HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 109316848-Oxo-nonanal

生成物 1

HCID 54440811HCID 54440811、化合物

実験手順

To a cooled (−40° C.) solution of 28-2 (10.8 g, 69.2 mmol) in 150 mL CH2Cl2 was added (carbethoxymethylene)triphenylphosphorane (24.1 g, 69.2 mmol) in 100 mL CH2Cl2 gradually over 15 min. The reaction mixture was stirred for 12 hr while it was warmed up to room temperature. After solvent removal, the residue was purified using silica gel flash chromatography (EtOAc/hexanes: 1:8 to 1:6) to afford the desired product 28-3 as an oil.

後処理

  1. customAfter solvent removal
  2. customthe residue was purified

出典と根拠

ORDレコード
ord-94788bf9160645a09e46345cdd689052
出典データセット
uspto-grants-2004_08
特許番号
US06784190B2

反応ノート

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