化工社化工社 化学情報印刷レポート · 研究参考用
Diisopropylethylamine → 2,4-Bis-(2-hydroxy-ethylamino)-6-(4-o-tolyl-piperazin-1-yl)-pyrimidine-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-(o-Tolyl)piperazine dihydrochloride | HCID 91964 | — |
| 反応物 | 4-Chloro-2,6-bis[(2-hydroxyethyl)amino]pyrimidine-5-carbonitrile | HCID 18753217 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2,4-Bis-(2-hydroxy-ethylamino)-6-(4-o-tolyl-piperazin-1-yl)-pyrimidine-5-carbonitrile | HCID 18753207 | — |
反応手順
In analogy to the procedure described in example 20b, 4-chloro-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile was treated with 1-(o-tolyl)-piperazine dihydrochloride in dioxane in the presence of N-ethyl-diisopropylamine at 80° C. to yield 2,4-bis-(2-hydroxy-ethylamino)-6-(4-o-tolyl-piperazin-1-yl)-pyrimidine-5-carbonitrile as an amorphous, light brown solid; MS: [M+H]+=398.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06673795B2 |
| 出典データセット | uspto-grants-2004_01 |
| ORD ID | ord-a6b4a5f043d34232bc7bc2addb83e502 |
| 出典メモ | uspto-grants-2004_01 |